According to a study by British researchersLarge-scale new researchObesity increases a man’s risk of dying from prostate cancer, however, the causal mechanism underpinning this link is unclear.
Prostate cancer is one of the most common cancers in men. It is a slow-growing cancer, so patients can live for many years after diagnosis.
Because of the prevalence of this cancer, researchers have been working to understand which factors may contribute to the development of more aggressive types of prostate cancer. Aurora Perez-Kornago, who led the new study at the University of Oxford, said understanding the risk factors for deadly prostate cancer could help patients avoid certain harmful lifestyles.
Knowing more about the factors that increase prostate cancer risk is key to preventing it, and age, family history, and black race are known risk factors, but they are immutable, so it’s important to discover risk factors that have the potential to change.
Previously, excess body fat was associated with a high incidence of fatal prostate cancer. The new study aims to provide a clearer picture of the relationship between weight and prostate cancer through a meta-analysis of 19 previous studies, including data from more than 2.5 million men.
The overall findings confirm previous doubts that weight gain is associated with an increased incidence of fatal prostate cancer. Quantitative studies have found that for every 5 percentage point increase in body mass index (BMI), a person’s risk of dying from prostate cancer increases by 10%.
The association between weight and fatal prostate cancer is not related to where a person’s weight is concentrated. But the researchers did calculate that for every 10 centimeters (3.9 inches) increase in waist circumference, the risk of dying from prostate cancer increased by 7 percent. Based on UK data, the study estimated that if men’s average BMI fell by 5 percentage points, the number of people dying from prostate cancer each year would be reduced by about 1,300 people.
The researchers say the link between weight and fatal prostate cancer may be clear, but still don’t know what drives that association. It is reasonable to think that higher body fat may drive the progression of prostate cancer. In fact, a 2018 study did hypothesize a mechanistic link between dietary fats and the progression of prostate cancer metastases.
But the researchers also note that other factors may also be at play, including differences in cancer detection between obese men and men of normal weight. For example, prostate-specific antigen (PSA) concentrations in blood samples may be lower in subjects with higher BMI, meaning that cancer risk may be detected at a later stage, leading to worse outcomes. Get more cutting-edge research progress visit: https://byteclicks.com