MEDICINE AND HEALTH

Chinese scholars have made new progress in the field of arterial embolism


Recently, Professor Fan Junbing’s team and collaborators from the School of Basic Medicine of Southern Medical University have made new progress in the research of structured iodinated oil emulsion microspheres based on Janus particles for arterial embolization. The study was published online in Nature Communications.

Schematic diagram of a structured iodinated oil emulsion droplet microsphere based on Janus granules for arterial embolization. Photo courtesy of the research team

Transcatheter arterial chemoembolization (TACE) is globally recognized as the mainstay of treatment for inoperable resectable liver cancer. Since the proposal of this therapy in 1978, liquid embolic agents represented by iodized oil have been widely used in chemotherapy-embolization therapy for first-line tumors and other diseases in clinical practice due to their advantages such as being able to visualize under X-ray and carry a variety of chemotherapy drugs.

However, after more than 40 years of clinical practice, researchers have found that the liquid iodide oil embolic agent system is very unstable, which is easy to cause vascular reversal and weak embolic effect. At the same time, iodized oil can also flow through blood vessels and be deposited into other tissues and organs, resulting in adverse complications such as non-targeted embolism.

In view of the above problems, the researchers gave full play to the advantages of basic and clinical cross-fusion, and after more than 3 years of continuous exploration, using the amphiphilic Janus particles developed by Fan Junbing’s team in the early stage, through their self-assembly at the iodidated oil-water interface, they constructed iodidated oil emulsion droplets with a liquid core of iodide oil droplets and a shell interface of Janus particles, so as to realize clinical liquid iodide oil microspheres.

The results of renal artery embolization in rabbit showed that compared with clinical iodide oil emulsion and embolized microspheres, the structured iodide oil emulsion droplet microspheres based on Janus particles could adapt to arterial vessels of different sizes and structures, and were deposited in arterial vessels for a long time, which significantly improved the stability of iodide oil embolic agent and avoided the complications caused by non-targeted embolization. At the same time, it gives liquid iodinated oil milk drop microspheres a new feature – excellent viscoelastic deformation ability, so that they can also reach thinner arterial vessels at the distal end through elastic deformation, thereby achieving terminal embolism, which greatly improves the arterial embolization effect.

In addition, the structured iodized oil emulsion droplet microspheres based on Janus granules also have the characteristics of high drug encapsulation efficiency, sustained drug release, and wide drug carrying spectrum, which is expected to provide a new strategy for improving the efficiency of clinical tumor chemotherapy and embolization. (Source: China Science News Zhu Hanbin)

Related paper information:https://www.nature.com/articles/s41467-023-41322-6



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