Schematic diagram of the study Courtesy of Westlake University
On May 30th, the team of Zheng Jusheng, a distinguished researcher of Westlake University, together with the team of Professor Chen Yuming of Sun Yat-sen University and the team of Professor Zhou Hongwei of Southern Medical University, published the relevant research results online in Nature-Communications under the title of “Intestinal Microbiota-Bile Acid Axis Connects Chronic Insomnia and Cardiometabolic Disease”.
The study revealed for the first time that the gut microbiome-bile acid axis may mediate the adverse effects of chronic insomnia on cardiometabolic diseases, identified the main bacterial genera and bile acids that mediate the positive association between chronic insomnia and cardiometabolic diseases, and found that long-term tea drinking habits help alleviate the imbalance of intestinal flora and bile acid metabolism caused by chronic insomnia.
Zheng Jusheng’s team cooperated with a number of domestic teams to take the Guangzhou Nutrition and Health Study (GNHS) as the discovery cohort and the Guangdong Gut Microbiome Project (GGMP) as the validation cohort. Using multi-site follow-up data (average 6.2 years) and high-throughput multi-omics data, the variation of the gut microbiome and bile acid metabolites caused by long-term chronic insomnia was found, revealing the key mediating role of the gut microbiome and bile acids in the chronic insomnia-cardiometabolic disease link.
The GNHS cohort was a Guangzhou cohort of more than 4,000 participants (aged 45-75 years) who followed all participants every three years from baseline recruitment between 2008 and 2013. The GGMP cohort is a large population of more than 10,000 participants (aged 18-97) from 14 different regions in Guangdong Province.
The study identified gut microbiome and bile acid markers affected by chronic insomnia and suggested for the first time that chronic insomnia can increase the risk of metabolic diseases by influencing the gut microbiome-bile acid axis. 6 years of long-term dietary follow-up information showed that long-term tea drinking habits helped alleviate intestinal flora and bile acid metabolism disorders caused by chronic insomnia. These findings provide new coping strategies and potential intervention targets for preventing or treating the adverse effects of chronic insomnia on metabolic health.
It is reported that Jiang Zengliang, assistant researcher of Westlake University, Zhuo Laibao, doctoral student of Sun Yat-sen University, and He Yan, professor of Southern Medical University, are the co-first authors of the paper, and Zheng Jusheng, Chen Yuming, and Zhou Hongwei are the co-corresponding authors of the paper. (Source: China Science Daily Wen Caifei)
Related paper information:https://doi.org/10.1038/s41467-022-30712-x