New progress has been made in the study of tibial chondrodynal dysplasia in broiler chickens

Broilers are important economic animals that provide poultry products. In recent years, in the process of continuous development of the quantity, yield and output rate of intensive breeding mode, the incidence of tibial cartilage dysplasia (TD) in broiler chickens has increased significantly due to the excessive weight gain rate and the limitation of feeding space. According to statistics, the incidence of TD in the world can reach 10%-30%, which is often ignored because it is often ignored as a subclinical symptom. TD not only inhibits broiler growth, but also causes a decline in meat quality, causing huge economic losses to the poultry industry. Since the pathogenesis of TD is not currently clear, there are currently no specific drugs to prevent and treat TD, so it is urgent to find effective molecular markers for TD.

Recently, Professor Wang Yan’s team from the College of Animal Science and Technology of Sichuan Agricultural University (hereinafter referred to as the College of Animal Sciences) published a research paper entitled “Comprehensive Analysis of mRNA and Non-Coding RNA and Their Mutual Regulation Mechanisms in Differential Expression in Chicken Tibia Cartilage Dysplasia induced by Fumei Bi-Induced Chicken Tibia” in the internationally renowned journal Ecotoxicology and Environmental Safety. Based on the demand for disease-resistant breeding in poultry breeding in China, this study annotates the differentially expressed mRNA, miRNA, circRNA and lncRNA in TD broiler chickens for the first time, and constructs an lncRNA/circRNA-miRNA-mRNA ceRNA regulatory network map.


CeRNA regulatory network diagram Courtesy of College of Animal Science and Technology, Sichuan Agricultural University

Taking Tianfu broiler chicken as the research material, the TD model was established to perform total transcriptome sequencing of tibia cartilage tissue in TD broiler chicken and healthy broiler chicken, and 141 mRNAs, 10 miRNAs, 23 lncRNAs and 35 circRNAs were differentially expressed. The study found that these differentially expressed mRNAs and non-coding RNAs are mainly enriched in TGF-β, MAPK, Hippo and other signaling pathways related to bone formation, and it is speculated that these differential genes may be related to the occurrence of TD. At the same time, the researchers performed ceRNA analysis on these differentially expressed genes and found that key molecules such as gga-miR-1737 and gga-miR-3540 have important regulatory roles in TD generation. This study provides new theoretical insights into the mechanism of TD occurrence in broiler chickens, and also provides effective molecular markers for the prevention and treatment of TD.

The research paper features Lu Yuxiang, a 2021 doctoral student of the Academy of Motion Sciences, as the first author, Jiang Yuru, a master’s student of the Class of 2020, as the co-first author, and Professor Wang Yan as the corresponding author. This research was funded by the National Natural Science Foundation of China and the Sichuan Provincial Breeding Research Project. (Source: China Science Daily Zhang Qingdan)

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