New results in the research of nanotherapy for fungal keratitis

Recently, the reporter learned from Shandong First Medical University that the collaborative team of Professor Gao Hua of the Institute of Ophthalmology affiliated to the university and Professor Zhang Shuping of the School of Biomedical Sciences has obtained new results in the research of fungal keratitis nanotherapy, which was published in Nature – Asian Materials.

Research on nanotherapy for fungal keratitis Photo courtesy of the research group

Fungal keratitis is one of the most common infectious eye diseases in developing countries, causing a large number of patients to go blind each year. Conventional antifungal therapy faces three major problems, one is the poor penetration of drugs; Second, the local residence time of the drug is short; Third, the severe inflammatory reaction caused by fungi and necrosis are easy to form scars after treatment, so that the cornea loses its transparency.

In order to solve these problems, Gao Hua and Zhang Shuping collaborated to prepare novel nano-eye drops with high permeability ROS response and controlled release for the treatment of fungal keratitis. The use of biparental glycol chitosan as a nanocarrier to contain the clinical drug voriconazole enables the target drug to penetrate the water-soluble and fat-soluble “double barrier” of the cornea, which solves the problem of poor permeability and low concentration of the drug in infected tissues.

According to reports, the self-assembled nano-eye drops can respond to the micro-slow-release antifungal VOR through ROS at the inflammatory lesion site of fungal infection to improve drug utilization, thereby solving the problem of affecting the treatment effect due to the short action time of the drug. At the same time, the response performance of the new nano-eye drops to ROS also realizes the clearance of local ROS, reduces the expression of inflammatory factors, and reduces the inflammatory response of corneal tissue, thereby reducing corneal tissue necrosis and corneal scarring.

The nano-eye drops have a significant therapeutic effect on mice with fungal keratitis, have the potential for clinical application, and have obtained invention patents, with broad prospects for commercial development.

This research was supported by the National Natural Science Foundation of China, the Taishan Young Scholars Program of Shandong Province, the Natural Science Foundation of Shandong Province, and the Academic Enhancement Program of Shandong First Medical University. (Source: China Science News, Liao Yang, Zhao Yingzuo)

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