MEDICINE AND HEALTH

Northwestern University has made new progress in the regulation of vascular aging and function


Vascular endothelial cell (ECs) aging plays a vital role in the process of vascular aging, and vascular aging promotes the occurrence and progression of cardiovascular disease. The mutation of Grb10 interaction GYF protein 2 (GIGYF2) is closely related to the pathogenesis of aging-related diseases, but its role in regulating senescence and dysfunction of vascular endothelial cells and its regulatory mechanism are still unclear.

Recently, Professor Yuyan Xiong’s team from the Department of Life Science and Medicine of Northwest University has made new progress in the study of the biological function and regulatory mechanism of GIGYF2 in vascular endothelial cell aging, and the results were published in Redox Biology, entitled “Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates.” vascular aging and function”。

Screenshot of the publication.

GIGYF2 is closely related to the pathogenesis of aging-related diseases. The study found that GIGYF2 was abnormally high expressed in the aorta of aging human ECs and aged mice; In non-aging ECs, overexpression of GIGYF2 promotes eNOS uncoupling, cellular senescence, endothelial dysfunction and activation of the mTORC1-SK61 signaling pathway, while rapamycin or antioxidant N-acetyl-L-cysteine treatment inhibits this phenomenon. Deprivation of STAU1 can significantly alleviate GIGYF2-induced aging, dysfunction and inflammation of young ECs. As an RNA-binding protein, GIGYF2 can enhance the stability of STAU1 mRNA, and the GIGYF2-STAU1 signaling axis promotes the translocation of mTORC1 to lysosomes by upregulating LAMTOR4 expression, thereby driving the activation of the mTORC1-S6K1 pathway. Furthermore, in mouse models, GIGYF2flox/flox Cdh-Cre+ mice protect aged mice from aging-related vascular endothelial dependent relaxation and arterial stiffness. Disruption of the GIGYF2-STAU1-mTORC1 signaling cascade may be a promising treatment for vascular aging and aging-related cardiovascular disease. (Source: Yan Tao, China Science News)

Northwestern University has made new progress in the regulation of vascular aging and function

Related paper information:https://authors.elsevier.com/sd/article/S2213-2317(23)00225-2



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