ENGINEERING TECHNOLOGY

Optical heat pump patch technology to achieve efficient directional delivery of macromolecules in cells


In recent years, researchers have often passed foreign macromolecules such as sugars, proteins, and genes to cells and tissues for cell and gene therapy. At present, a variety of different intracellular macromolecule delivery strategies have been developed, including chemical methods (such as liposomes, polycations, etc.) and physical and mechanical methods (such as electroporation, photoporation, nanoneedles, etc.). However, there is still a lack of a universal macromolecule delivery strategy that is efficient, non-destructive, and suitable for in vivo/in vivo.

The photothermal method has the advantages of high throughput, wide applicability, non-destructive and remote operation. However, photothermal methods are difficult to achieve directed transport of foreign molecules, which limits intracellular delivery efficiency. Although there has been a hot discussion of attempts to achieve directional transport of exogenous molecules through artificial extrusion, the efficiency of photothermal-mediated intracellular transport is still limited by differences in operation time. Therefore, directed transport of exogenous molecules by laser becomes key to designing universal intracellular delivery strategies in vivo/in vitro.

Recently, Professor Chen Hong of the School of Chemistry, Chemical Engineering and Materials Science of Soochow University and Dr. Wang Lei of Jiangsu Baisaifei Company collaborated to develop a new technology called photoheat pump (PTP) patch for efficient and non-destructive delivery of therapeutic macromolecules to target cells and tissues, suitable for in vitro and in vivo applications. The research was published in Advanced Materials.

Schematic diagram of the principle of directed delivery of macromolecules in cells, realized by photoheat pump (PTP) patch

Researchers pointed out that PTP patches provide new possibilities for the treatment of subcutaneous hair follicles, blood vessels, nerves and subcutaneous tumors. In addition, they demonstrated the potential application of PTP patches in transducing immune checkpoint blockade therapy drugs, providing a broad platform for the treatment of skin diseases. (Source: Zhang Qingdan, China Science News)

Related paper information:https://doi.org/10.1002/adma.202304365



Source link

Related Articles

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to top button