INFORMATION TECHNOLOGY

Progress has been made in the study of microfluidics-magnetics for the detection of tumor exosomes


Tumor-derived exosomes (TDEs) secreted by tumor cells have broad clinical application prospects. The detection of TDEs is of great significance for early diagnosis, efficacy evaluation and prognosis analysis of tumors, as well as for the highly sensitive quantitative detection of TDEs.

Recently, the research group of Mi Xianqiang, the eighth research laboratory of the Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, and the research group of Ye Zhaofeng of ShanghaiTech University have jointly developed a set of tumor exosome detection system based on a new magnetic detection system. In this work, a microfluidic Magnetic Detection System (μFMS) composed of a chip module, a fluidic module and a magnetic detector was constructed. This system was used to monitor exosomes secreted by a human glioma cell line (U251 cells) with a sensitivity of 1.98×103 particle/mL. Further studies have shown that the system is suitable for the detection of TDEs in complex systems. The new μFMS magnetic detection system provides a new technology for the detection of clinical tumor markers.

The related research results were published in Microsystems and Nanoengineering under the title of Microfluidic magnetic detection system combined with a DNA framework-mediated immune-sandwich assay for rapid and sensitive detection of tumor-derived exosomes (Microsystems & Nanoengineering). The research work has been supported by the Shanghai Outstanding Academic Leader Program, the Shanghai Municipal Science and Technology Commission, the Chinese Academy of Sciences, and the National Key R&D Program. (Source: Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences)

Progress has been made in the study of microfluidics-magnetics for the detection of tumor exosomes

Related Paper Information:https://doi.org/10.1038/s41378-023-00617-w

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