Researchers propose new strategies to promote diabetic wound healing

Recently, the team of Fan Zengjie and Liu Bin, professors of Lanzhou University School of Stomatology, and the team of Sun Luyi, professor of the University of Connecticut, published research results in Science Advances, proposing a new strategy to promote diabetic wound healing and prevent scar formation through self-powered enzyme-linked microneedle patches.

Research roadmap. Photo courtesy of the research group

Pathological features such as hyperglycemia, bacterial infection, and long-term inflammation are the main causes of difficulty and difficulty in healing diabetic wounds. In severe cases, the risk of amputation may be increased. In addition, like other wounds, diabetic wounds are often accompanied by scarring after healing, which is also one of the current clinical problems.

In view of the pathological characteristics of diabetic wounds, this study innovatively designed and manufactured a self-powered enzyme-linked MN patch by making full use of the minimally invasive, painless, self-fixation and other technical advantages of microneedling (MN) patch, combined with the characteristics of biofuel cells that can use sugar as fuel, good biocompatibility, stable and durable current. The patch consists of an anode and cathode MN array, which contains glucose oxidase (GOX) and horseradish peroxidase (HRP) encapsulated by ZIF-8 nanoparticles, respectively. Through the enzymatic cascade reaction in this MN patch, it can effectively reduce local hyperglycemia in diabetic wounds while generating stable microcurrents to promote rapid healing of diabetic wounds.

The results of the study showed that the treatment of diabetic wounds (wound area 1 cm2) with the MN patch can achieve rapid, complete and scar-blocking healing within three weeks, thanks to the synergistic effect of the MN patch in terms of hypoglycemic, antibacterial, anti-inflammatory and bioelectric stimulation. Therefore, this study proposes an effective method to quickly promote the healing of diabetic wounds and prevent scarring, which is expected to change the current situation of difficult healing of diabetic wounds, and has broad application prospects in clinical wound repair. (Source: China Science News, Wen Caifei, Faisha)

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