MEDICINE AND HEALTH

Serine provides a new target for nutrition regulation and disease treatment in livestock and poultry


Serine plays an important role in maintaining metabolic homeostasis and body health, and is of great significance in the clinical treatment of metabolic syndrome, immune system diseases and neuropathy. The de novo serine synthesis pathway is the main source of serine in vivo, and its synthesis rate may be affected by negative feedback regulation and the synergy of transcription factors and tumor suppressors.

The reporter learned from the Institute of Subtropical Agroecology of the Chinese Academy of Sciences on June 26 that Yin Yulong’s scientific research team, academician of the Chinese Academy of Engineering and chief researcher of the Institute of Subtropical Ecology, proposed a framework for serine metabolism to maintain metabolic homeostasis and treat human diseases, and found that serine has different degrees of improvement on sow reproductive performance, piglet immune function and antioxidant function, and meat quality of fattening pigs, which indicates the importance of serine to the growth and development process of livestock and poultry. It also provides a new target for the clinical treatment of serine for metabolic diseases and tumors.

Summary diagram of the study. Photo courtesy of the interviewed team

The review article was recently published in the Cell journal Trends in Endocrinology & Metabolism, with He Liuqin, a professor at Hunan Normal University, as the first author, and Li Tiejun, an academician of Yin Yulong and a researcher at the Institute of Subtropical Ecology, as the corresponding author.

Serine has been studied as a new target for the clinical treatment of metabolic syndrome, immune system diseases and neuropathy, but its role in nutrition and signal regulation has not been systematically summarized. Under normal physiological conditions, endogenous serine is sufficient to meet normal needs, while in pathological or stressed states, serine metabolism is disrupted.

Numerous studies have shown that serine has great potential in treating diabetes, fatty liver, brain diseases and immune system disorders. Recent research by Professor He Liuqin, a member of the Academician Yin Yulong team, has further confirmed that serine in vivo and in vitro can improve the body’s immunity and antioxidant capacity, regulate the body’s intestinal flora, and promote the growth and development of piglets.

The results focus on serine metabolism, demonstrating the importance of serine for animal health under normal physiological and stress conditions. In particular, the serine from the cephaloserine synthesis pathway (SSP) plays a crucial role in the targeted regulation of immune response, cell proliferation, and lipid/protein metabolism. Serine from SSPs may be a stress signaling agent, providing new insights into the relationship between metabolic homeostasis and disease.

The study discusses how serine signaling regulates metabolic and anti-stress processes, including enhancing antioxidant stress, boosting immunity, regulating energy and lipid metabolism, improving gut flora, and promoting nervous system development. The researchers also propose a possible framework that a better understanding of the regulatory mechanisms of serine metabolism could provide new targets for the clinical treatment of metabolic diseases and tumors.

According to reports, research in this area has stimulated new interest in the role of serine in metabolic homeostasis and health regulation. In the future, the team of Academician Yin Yulong will focus on the combination treatment of endogenous restriction of serine synthesis and exogenous dietary intervention, and strive to create new uses of serine in the treatment of diseases, especially for the treatment and intervention of cancer, aging, fatty liver disease and neurological diseases. Serine metabolism may be related to the occurrence of animal diseases, and the team will conduct in-depth research on serine-derived immune responses and antioxidants to promote the growth and development of livestock and poultry, which will help people further understand the mechanism of serine’s impact on livestock and poultry health. (Source: Wang Haohao, China Science News)

Related paper information:https://doi.org/10.1016/j.tem.2023.03.001



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