MEDICINE AND HEALTH

Studies have found that 30 and 50 years old are the cut-off point for women to exacerbate aging


On July 28, the Institute of Zoology, Chinese Academy of Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences and Quzhou People’s Hospital cooperated to publish a research paper online in the journal Med, which systematically excavated the biological markers of Chinese women’s aging across 5 dimensions, established a multi-level composite clock for Chinese women, and used the clock system to reveal the dynamic changes of Chinese women’s aging and the potential intervention effect of hormone replacement therapy on female aging.

The establishment of the aging clock of Chinese women and its application Figure from the paper

In daily life, some people look younger than their peers, and some look older, suggesting that the biological age of humans is often not exactly the same as the age of ID cards, and there is an urgent need to establish an “aging clock” that can assess the biological age of humans.

This study took women aged 20-66 in Quzhou, Zhejiang Province as samples, using multi-parameter phenotypic group, (single-cell) transcriptome, proteome, metabolome and microbiome, combined with artificial intelligence and other analysis methods, to explore the multi-dimensional characteristics of Chinese women’s aging, and identify a series of new aging biomarkers in phenotypic level, transcription level, protein level, metabolic level and other aspects.

By integrating multi-omics data, the researchers found that the aging of Chinese women’s health status was accompanied by significant changes in three aspects: inflammatory activation, hormonal regulation disorders, and degeneration of multiple tissues (mainly manifested as bone density loss, decreased lung function, and accumulation of markers of liver injury degeneration). Based on this, the researchers established a multidimensional aging clock for Chinese women, including face, phenotype, transcription, protein and metabolism.

The study also found that the women experienced significantly more aging changes at the age of 30 and 50. Around the age of 30, it is mainly manifested as the accumulation of lipids and the decrease of steroids at the metabolic level, and around the age of 50, the aging process at multiple levels such as organs, cells and molecules undergoes drastic changes, including the steep rise or fall of a variety of age-related height-related indicators.

Zhang Weiqi, a researcher at the Beijing Institute of Genomics, Chinese Academy of Sciences, introduced that because 30 and 50 years old roughly correspond to the dividing point between fertility and menopause, these events may lead to large fluctuations in female endocrine levels, which once again shows that changes in hormone levels may be the key factors affecting women’s aging.

Liu Guanghui, a researcher at the Institute of Zoology, Chinese Academy of Sciences, said that the study provides a paradigm and resources for the establishment and development of human composite aging clocks. In the future, it is expected to analyze the aging characteristics of Chinese groups from the system dimension, establish an aging index to evaluate human physiological age, and help the development of systematic geriatrics. (Source: Liu Runan, China Science News)

Related paper information:https://doi.org/10.1016/j.medj.2023.06.010



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