CHEMICAL SCIENCE

The new catalytic system enriches the conversion route of organic sulfides


Organosulfur compounds are one of the most basic building blocks of organic synthesis and are also ubiquitous in many natural products and fossil resources. Therefore, the exploration of the activation mode and mechanism of C-S bonds has attracted extensive attention from researchers. Recently, Dai Wen’s team, a researcher at the Dalian Institute of Chemical Physics, Chinese Academy of Sciences, has made new progress in the research on the high-value conversion and utilization of heterogeneous catalytic organic sulfides. The team used the graphene-coated cobalt (Co) nanoparticles and atomically dispersed Co-Nx synergistic catalytic strategy to achieve the oxidative cleavage of a series of aromatic and aliphatic organic sulfide C-S bonds to the conversion of nitrile and amide compounds. The results were published in Nature Communications.

Schematic diagram of transformation (photo provided by Dalian Chemical Corporation)

At present, important progress has been made in the cross-coupling of C-S bonds catalyzed by homogeneous transition metals and the reduction and cleavage of C-S bonds. In contrast, the oxidative cleavage and functional grouping of C-S bonds in organic sulfides are still not fully understood due to the difficulty of controlling chemical selectivity under oxidation conditions.

In the context of the above research, Devon’s team developed a simple and efficient heterogeneous catalytic system. Under the condition of molecular oxygen as oxidant and ammonia as ammonia source, graphene-coated Co nanoparticles and atomically dispersed Co-Nx synergistically catalyze various types of aromatics, and the selective regulation of nitrile and amide products was realized by changing the reaction conditions. It is also found that the scale-up experiment of this method still has high product selectivity, and the catalyst still maintains a stable product yield after multiple cycles, which can provide a reference for industrialization. It is worth mentioning that this method has also been well applied in the oxidative desulfurization reaction of heavy oil.

This method not only enriches and upgrades the conversion route of organic sulfides, but also provides an efficient and versatile new way for the transformation and modification of lead compounds such as sulfhydryl drugs, pesticides and bioactive molecules. (Source: Sun Danning, China Science News)

Related paper information:https://doi.org/10.1038/s41467-023-38614-2



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