In recent years, with the improvement of people’s living standards, there are more and more patients with fatty liver, and the disease progresses and gradually develops into fatty liver fibrosis, causing liver function damage and seriously affecting people’s lives.
In this regard, the research group of Professor Qi Yajuan of the School of Basic Medicine of North China University of Science and Technology cooperated with researchers from Texas A&M University in the United States to find that knocking out the FoxO1 gene in the liver can reduce liver inflammation and TGF-β1-mediated activation of liver stellate cells into fibroblasts by downregulating the expression of cytokine TGF-β1, thereby reducing the production of collagen fibers in the liver and delaying the process of liver fibrosis.
Schematic diagram of research results Courtesy of North China University of Science and Technology
The research results were recently published in the internationally renowned journal Cellular and Molecular Gastroenterology and Hepatology.
It is reported that the study suggests that the liver FoxO1 gene may be one of the targets for the prevention and treatment of liver fibrosis, which provides an important reference for the clinical development of anti-liver fibrosis drugs. (Source: Chen Bin, China Science News)
Related paper information:https://doi.org/10.1016/j.jcmgh.2023.08.013