The study revealed the epidemic transmission and genetic evolution of porcine coronavirus

Recently, the team of Professor Cao Yongchang of the College of Life Sciences of Sun Yat-sen University cooperated with Wen Group, Wen Research Institute, Nanjing Agricultural University Research Institute, etc., and under the funding of the “13th Five-Year Plan” and “14th Five-Year Plan” national key research and development plans, the research revealed the epidemic transmission and genetic evolution of swine coronavirus. THE STUDY WAS PUBLISHED AS A COVER ARTICLE IN MOLECULAR BIOLOGY AND EVOLUTION.

The reporter learned that the cover uses traditional Chinese elements such as Tai Chi Bagua and Dunhuang murals as the basis for design, showing “the road is one foot high, the magic is one foot high”, that is, the genetic evolution of pig diarrhea coronavirus breaks through the immune barrier of traditional vaccines.

Cover of the current issue. Photo courtesy of the research team

Porcine epidemic diarrhea virus (PEDV) is a genus of coronaviruses α the coronavirus family. The pathogen is a newly discovered coronavirus in the 70s of the 20th century, which has been endemic locally and globally for many times. Since 2010, the virus has widely broken out in China’s pig industry, and has continued to spread in an epidemic to this day, causing a large number of piglets to die and bringing huge economic losses to the pig industry. Therefore, in-depth study of the evolution of PEDV epidemic in China and the world is of great significance for disease prevention and control and vaccine development.

Cao Yongchang’s team has been paying close attention to the epidemic spread of PEDV in China, long-term monitoring of the clinical spread of PEDV in China, collecting a total of 149869 PEDV-positive disease materials in the 11 years from 2011~2021, and separating and sequencing the whole genome sequences of 65 PEDV strains. The team further conducted in-depth research on the epidemic propagation of PEDV in China and the world through bioinformatics and molecular biology.

This study is the first to clarify the classification of PEDV in the world based on the haplotype algorithm, and found that the use of commercial vaccines may accelerate the rate of PEDV evolution, and molecular biology experiments have further discovered specific epitopes that can identify the classification of different strains of PEDV. (Source: China Science News Zhu Hanbin)

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