ENGINEERING TECHNOLOGY

This photodynamic drug significantly reduces tumor stem cell activity


Qin Yan, a researcher at the Institute of Biophysics of the Chinese Academy of Sciences, and Wang Tianyu and Jiang Jianzhuang, professors of the University of Science and Technology Beijing, cooperated to synthesize a new photodynamic drug for the first time to target the ribosomes of tumor stem cells, obtain good effects of tumor ablation, and deeply explore the molecular mechanism of anti-tumor. The results were published online in Biomaterials on September 17.

Ribosomes in each mammalian cell have tens of millions of copies and are the possessors of the cell’s material and energy and the synthesizers of proteins. In rapidly proliferating cells, ribosomes occupy a higher proportion of substances and energy, which is one of the important markers of tumor stem cells and has a significant correlation with the surface markers of many tumor stem cells (such as CD133, CD44, etc.). Ribosomal-targeting drugs have made the greatest contribution to the extension of human lifespan, so far the broad-spectrum antibiotics targeted by ribosomal targets are the largest types of antibacterial drugs approved by the United States Food and Drug Administration and other international drug regulatory organizations, especially macrolides (such as erythromycin and its derivatives of 14 yuan ring, azithromycin of 15 yuan ring, acetyl spiramycin of 16 yuan ring), aminoglycosides (such as gentamicin, kanamycin, streptomycin, etc.), and tetracycline, all of which are drugs that target ribosomes, antibacterial for humans, The fight against infection has made a great contribution. Since the clinical use of broad-spectrum antibiotics in the 1940s, the average life expectancy of humans has more than doubled from their 30s to their 70s worldwide.

Photodynamic therapy (PDT) is a type of treatment plan that uses photosensitizers and chemotherapy drugs to assemble into nanodrugs, target tumor tissue, and use light as a switch for drug release and effectiveness. The researchers first synthesized nanomaterials targeting small peptides and photosensitizers that targeted ribosomes, and obtained good in vitro cancer suppression effects under the irradiation of far-infrared light, especially the significant reduction of tumor stem cells and the large number of ribosomal inactivations. Experiments in mice (conventional mice and immunodeficient mice) have obtained a good antitumor effect of tumor ablation, mainly due to the efficacy of PDT, the root cause of which is severe damage to the CSC ribosome.

Photodynamic drug anti-tumor stem cell and ribosomal inhibition model Qin Yan courtesy photo

Qin Yan, a researcher at the Institute of Biophysics, Wang Tianyu and Jiang Jianzhuang, professors at the University of Science and Technology Beijing, and Ding Fang, an assistant researcher at the Institute of Biophysics, are co-corresponding authors of this paper. Wang Jian, experimenter of Qin Yan’s research group, is the first author of this paper, and Yang Baojian, a doctoral student at the University of Science and Technology Beijing, is the first author of this paper. Experimenters of the Institute of Biophysics, such as Lv Chaofan, Hao Junfeng, and doctoral student Sun Lei, also participated in the study. The research was funded by the National Key Research and Development Program and the National Natural Science Foundation of China. The Institute of Biophysics laboratory animal platform provided important technical support for the study. (Source: China Science Daily, Feng Lifei)

Related Paper Information:https://doi.org/10.1016/j.biomaterials.2022.121812



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