Why don’t some people get sick often? Immune resilience hides the answer

U.S. scientists have found that immune resilience — the ability to maintain or restore immune function — may be related to the ability to respond to infectious and inflammatory diseases. Through the investigation of multiple infectious and inflammatory disease studies, the new findings may shed light on why some people stay healthier throughout their lives. The study was published June 13 in Nature Communications.

Why do some people live longer and are less susceptible to infectious and inflammatory diseases? This is a question that is not yet fully understood. Infections and inflammatory diseases lead to changes in the immune system, and the magnitude and quality of the response to the disease can vary from person to person. It has been suggested that the best response to infectious and inflammatory diseases is related to life expectancy, but further research is needed.

Sunil Ahuja of the University of Texas Health Sciences Center in San Antonio and colleagues investigated a range of data based on human and animal studies to estimate immune resilience in each setting. They surveyed more than 48,500 people and multiple animal models and found that some people maintained immune resilience from exposure to different infectious and inflammatory diseases and during aging.

The presence of immune resilience in infectious or inflammatory diseases is associated with longer life expectancy and favorable health outcomes for a range of diseases studied including AIDS, symptomatic influenza infection, coronavirus, sepsis, and recurrent skin cancer. The study also suggests that optimal immune resilience is detectable at all ages, may be more common in women, and may be associated with favorable immune-dependent health outcomes.

The researchers believe that immune resilience could be used for monitoring in the future and may inform prognosis and manage health outcomes, including longevity and infection response. However, further research is needed to determine the effectiveness and usefulness of measuring immune resilience for diagnosing, predicting, and managing inflammatory and infectious diseases. (Source: China Science News Feng Lifei)

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